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Who should have a Down’s syndrome screening test?
Can maternal medical problems alter the Down’s result?
Is an ultrasound dating scan needed before screening?
There is no CF in my family so can I be a carrier ?
Our other children are well so can this baby have a problem ?
Does maternal age affect DNA screening risk?
I am not yet pregnant; can I be DNA screened for CF, Fragile X , SMA, Alef8?
Who should have a Down’s syndrome screening test?
Older women who have been offered prenatal diagnosis but are unsure about accepting it, and younger woman, who would not normally be offered prenatal diagnosis. Both can use the test to decide what to do next.
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Can maternal medical problems alter the Down’s result?
Blood marker levels in insulin dependent diabetes are altered, particularly AFP, but we allow for this. Rarer problems may alter marker levels, so we need to know if you have one.
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Is an ultrasound dating scan needed before screening?
We can use the last menstrual period (LMP) date to estimate gestation and calculate MoMs. Gestational errors will distort the marker profile, so if there is doubt about the LMP, a scan is preferred. DNA screening is not gestation dependent.
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There is no CF in my family so can I be a carrier ?
Most CF infants are born to couples with no family history.
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Our other children are well so can this baby have a problem ?
Having had unaffected children reduces the risk but is no guarantee against a DNA abnormaility.
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Does maternal age affect DNA screening risk?
No. Chromosomal anomalies are the only common disorders related to age.
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I am not yet pregnant; can I be DNA screened for CF, Fragile X , SMA, Alef8?
Yes. LSC will carry out tests on couples before pregnancy
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